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Eleven unselected 47,XXX girls, now 15 to 22 years of age, have been observed from birth in a prospective study of children with sex chromosome anomalies. A description of their growth and development is presented. The 47,XXX infants were not generally distinguishable from chromosomally normal children in the first year of life, even though there was a slight delay in neuromotor development. By 2 years of age, developmental delays in speech and language often became evident, and speech therapy was often necessitated in the preschool years. Early school problems included speech and language deficiencies, lack of coordination, poor academic performance, and immature behavior; these persisted throughout the school years. By high school age, a 47,XXX girl was generally tall and often subject to somatic complaints.

Trisomy X is a sex chromosome anomaly with a variable phenotype caused by the presence of an extra X chromosome in females 47,XXX instead of 46,XX. It is the most common female chromosomal abnormality, occurring in approximately 1 in 1, female births. The most common physical features include tall stature, epicanthal folds, hypotonia and clinodactyly. Seizures, renal and genitourinary abnormalities, and premature ovarian failure POF can also be associated findings.

A girl is a young female human , usually a child or an adolescent. When she becomes an adult, she is described as a woman. The term girl may also be used to mean a young woman , [1] and is sometimes used as a synonym for daughter. The treatment and status of girls in any society is usually closely related to the status of women in that culture. In cultures where women have a low societal position, girls may be unwanted by their parents, and the state may invest less in services for girls.